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Showing 1–7 of 7 results
Advanced filters: Author: Gopi Shah Clear advanced filters

  • Sample orientation is crucial to ensure optimal image quality in light microscopy. Here the authors enable multi-axis orientation of fixed mouse embryos and shrimp, and live zebrafish embryos and larvae by introducing magnetic beads and rotating the sample with a magnetic field in a microscope.

    • Frederic Berndt
    • Gopi Shah
    • Jan Huisken
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • The precise cell dynamics of early development have not yet been visualized. Here, the authors use custom 4-lens light sheet microscopy to image and analyze the dynamics of all three fluorescently labeled germlayers, yielding a comprehensive, pan-embryo description of early zebrafish gastrulation.

    • Gopi Shah
    • Konstantin Thierbach
    • Jan Huisken
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Numerous tissues are derived from the lateral plate mesoderm (LPM) but how this is specified is unclear. Here, the authors identify a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corresponding territories of several chordates, including chicken, axolotl, lamprey, Ciona, and amphioxus.

    • Karin D. Prummel
    • Christopher Hess
    • Christian Mosimann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Systematic large-scale analysis of embryonic development requires the processing of large amounts of microscopy data. Here Schmid et al.solve this problem by developing a high-speed imaging system that projects zebrafish embryos onto a ‘world map’ in real time, revealing characteristic migration patterns in the early endoderm.

    • Benjamin Schmid
    • Gopi Shah
    • Jan Huisken
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776