Nature Search

Wandering why

Richard G. Gordon
News & Views08 May 1997
Nature

Volume: 387, P: 131-133
Effect of age on benzodiazepine-induced behavioural convulsions in rats

Gordon A. Barr
Ted Lithgow
Research31 Mar 1983
Nature

Volume: 302, P: 431-432
A long journey to reproducible results

Replicating our work took four years and 100,000 worms but brought surprising discoveries, explain Gordon J. Lithgow, Monica Driscoll and Patrick Phillips.

Gordon J. Lithgow
Monica Driscoll
Patrick Phillips
Comments & Opinion24 Aug 2017
Nature

Volume: 548, P: 387-388
A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

Chamoli et al. identified MIC, a benzocoumarin molecule, that promotes longevity in C. elegans by inducing mitophagy via DAF-12/FXR and HLH-30/TFEB, and they demonstrate a conserved MIC efficacy in mammalian cells, indicating potential broader relevance.

Manish Chamoli
Anand Rane
Julie K. Andersen
Research13 Nov 2023
Nature Aging

Volume: 3, P: 1529-1543
Evolution of lifespan in C. elegans

David W. Walker
Gawain McColl
Gordon J. Lithgow
Research18 May 2000
Nature

Volume: 405, P: 296-297
Leather Industries Laboratory Book of Analytical and Experimental Methods

J. GORDON PARKER
Books & Arts15 Oct 1908
Nature

Volume: 78, P: 602-603
Accelerating the promise of geroscience through The Academy of Health & Lifespan Research

Nir Barzilai
Risa Starr
Andrea B. Maier
Correspondence07 Mar 2025
Nature Aging

Volume: 5, P: 529-531
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.

Mark Lucanic
W. Todd Plummer
Patrick C. Phillips
ResearchOpen Access21 Feb 2017
Nature Communications

Volume: 8, P: 1-13
The architecture and stabilisation of flagellotropic tailed bacteriophages

Flagellotropic phages spin down flagella to reach the bacterial surface and must withstand remarkable drag forces. Here authors show how two nested sets of chainmail stabilise the viral head and a beta-hairpin regulates the formation of the robust yet pliable tail, characteristic of siphoviruses.

Joshua M. Hardy
Rhys A. Dunstan
Fasséli Coulibaly
ResearchOpen Access27 Jul 2020
Nature Communications

Volume: 11, P: 1-11
Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

Metabolic reprogramming during Dietary Restriction (DR) activates cytoprotective gene expression. Here the authors show that PUFAs generated during DR signal via the p38-MAPK pathway to enhance cytoprotective gene expression, contributing to increased longevity.

Manish Chamoli
Anita Goyala
Arnab Mukhopadhyay
ResearchOpen Access25 Sept 2020
Nature Communications

Volume: 11, P: 1-13
Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Analyses of 2,083 globally distributed group A Streptococcus (GAS) genomes enable the development of a compendium of all GAS vaccine antigen sequences, providing a platform for population-genomics-informed vaccine design.

Mark R. Davies
Liam McIntyre
Mark J. Walker
Research27 May 2019
Nature Genetics

Volume: 51, P: 1035-1043
Author Correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Mark R. Davies
Liam McIntyre
Mark J. Walker
Amendments and Corrections19 Jul 2019
Nature Genetics

Volume: 51, P: 1295
Cost-free longevity in mice?

Studies of worms have revealed hundreds of proteins that, when mutated, extend lifespan. Can this work tell us anything about mammalian ageing? A look at the effects of one such protein on lab mice suggests that it can.

Gordon J. Lithgow
Matthew S. Gill
News & Views09 Jan 2003
Nature

Volume: 421, P: 125-126
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

Mark Lucanic
Jason M. Held
Matthew S. Gill
Research11 May 2011
Nature

Volume: 473, P: 226-229
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

Silvestre Alavez
Maithili C. Vantipalli
Gordon J. Lithgow
Research30 Mar 2011
Nature

Volume: 472, P: 226-229
From discoveries in ageing research to therapeutics for healthy ageing

The milestones that mark the advances in ageing research, the medical, commercial and societal implications of ageing and the different ageing pathways and processes that are associated with ageing are discussed.

Judith Campisi
Pankaj Kapahi
Eric Verdin
Reviews10 Jul 2019
Nature

Volume: 571, P: 183-192

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Wandering why

Effect of age on benzodiazepine-induced behavioural convulsions in rats

A long journey to reproducible results

A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

Evolution of lifespan in C. elegans

Leather Industries Laboratory Book of Analytical and Experimental Methods

Accelerating the promise of geroscience through The Academy of Health & Lifespan Research

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

The architecture and stabilisation of flagellotropic tailed bacteriophages

Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Author Correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Cost-free longevity in mice?

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

From discoveries in ageing research to therapeutics for healthy ageing

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