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Showing 1–10 of 10 results
Advanced filters: Author: Gotthold Fläschner Clear advanced filters

  • Measuring the mass of individual microbial cells remains challenging. Here, the authors present a cell balance to monitor the proliferation of single budding yeast cells under culture conditions in real time, showing that single cells increase total mass in multiple linear segments of constant growth rates.

    • Andreas P. Cuny
    • K. Tanuj Sapra
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix viscoelastic cues, through a coordinated interaction with molecular clutch mechanisms.

    • Mariana A. G. Oliva
    • Giuseppe Ciccone
    • Manuel Salmeron-Sanchez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • A picobalance consisting of an optically excited microcantilever has been developed and used to measure the masses of individual healthy and virus-infected cells at high temporal and mass resolutions in culture conditions.

    • David Martínez-Martín
    • Gotthold Fläschner
    • Daniel J. Müller
    Research
    Nature
    Volume: 550, P: 500-505

  • There is increasing interest in measuring the mechanical properties of living cells. Here, the authors develop a method to simultaneously measure the cell mass and two parameters related to its natural oscillation or resonance frequencies.

    • Sophie Herzog
    • Gotthold Fläschner
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • While rheology studies have contributed to the understanding of the viscoelastic properties of living cells, the use of higher frequencies promises elucidate the link between cellular and molecular properties. Here authors introduce a rheological assay that measures the cell mechanical response across a continuous frequency range ≈ 1 – 40 kHz.

    • Gotthold Fläschner
    • Cosmin I. Roman
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Mechanobiology describes how biological systems respond to mechanical stimuli. This Review surveys basic principles, advantages and limitations of applying and combining atomic force microscopy-based modalities with complementary techniques to characterize the morphology, mechanical properties and functional response of complex biological systems to mechanical cues.

    • Michael Krieg
    • Gotthold Fläschner
    • Daniel J. Müller
    Reviews
    Nature Reviews Physics
    Volume: 1, P: 41-57

  • Facilitated water permeation through narrow biological channels is fundamental for all forms of life, but despite its significance the energetics of water permeation are still elusive. Here, the authors use accurate activation energy and single channel permeability measurements to estimate the entropic barrier of water permeation through Aquaporin-1.

    • Johann Wachlmayr
    • Gotthold Fläschner
    • Andreas Horner
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10