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Showing 1–3 of 3 results
Advanced filters: Author: Grace N. Hibshman Clear advanced filters

  • CRISPR-Cas9 is a powerful tool, but the strict requirement for an “NGG” protospacer-adjacent motif (PAM) sequence limits the number of editable genes. Here the authors combine enzyme kinetics, cryo-EM, and single-molecule imaging to determine how SpRY interrogates DNA and recognises target sites for cleavage.

    • Grace N. Hibshman
    • Jack P. K. Bravo
    • David W. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Cryo-electron microscopy structures of Cas9 during mismatch cleavage provide insight into the mechanisms that control off-target effects of Cas9, which will aid in the future design of high-fidelity Cas9 variants with reduced off-target cleavage.

    • Jack P. K. Bravo
    • Mu-Sen Liu
    • David W. Taylor
    ResearchOpen Access
    Nature
    Volume: 603, P: 343-347