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Showing 1–4 of 4 results
Advanced filters: Author: Graeme McAlister Clear advanced filters

  • The two major mechanisms for peptide fragmentation by mass spectrometry, collision-activated dissociation (CAD) or a newer method, electron transfer dissociation (ETD), display different efficacies for different peptide chemistries. A decision tree algorithm, which can be embedded into instruments with both CAD and ETD capabilities, selects the optimal fragmentation method to improve the chances of successful peptide identification.

    • Danielle L Swaney
    • Graeme C McAlister
    • Joshua J Coon
    Research
    Nature Methods
    Volume: 5, P: 959-964

  • Structural insights demonstrating small-molecule-mediated dimerization of BRD4 bromodomains led to the development of biBET, a compound that potently inhibits BRD4–acetyl-lysine interactions by bivalent binding to tandem bromodomains.

    • Michael J Waring
    • Huawei Chen
    • Yi Yao
    Research
    Nature Chemical Biology
    Volume: 12, P: 1097-1104

  • A mass spectrometry instrument control method—QuantMode—allows accurate, large-scale, multiplexed quantitative proteomics measurements using isobaric tagging by removing the problem of precursor interference. Also in this issue, Ting et al. provide a different solution to the same problem.

    • Craig D Wenger
    • M Violet Lee
    • Joshua J Coon
    Research
    Nature Methods
    Volume: 8, P: 933-935