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Showing 1–5 of 5 results
Advanced filters: Author: Graeme Poston Clear advanced filters
  • Conducting high-quality prospective clinical trials in surgical oncology remains a challenge. The authors of this Perspectives examine some of the failures in published surgical oncology trials and discuss why they failed, and provide a critical assessment of the established prospective trial methodology in oncological practice and how these methods might be used more effectively in future evaluation of cancer-surgery practice.

    • Serge Evrard
    • Pippa McKelvie-Sebileau
    • Graeme Poston
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 13, P: 55-62
  • Surgery is the oldest oncological discipline and remains the cornerstone of treatment for most patients with cancer. However, the way surgery is used to treat cancer has evolved and outcomes continue to improve as a result of greater biological understanding, relentless technical innovation and a paradigm shift towards multimodal treatment. In this Perspectives, the authors discuss the developments in cancer surgery that have occurred over time and provide an overview of the key uses of surgery in the current era of multidisciplinary cancer care.

    • Lynda Wyld
    • Riccardo A. Audisio
    • Graeme J. Poston
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 12, P: 115-124
  • Interventional oncology aims to develop new disease-modifying treatment options beyond conventional surgical and oncological therapies. Clinical investigators should incorporate measures of cost-effectiveness and patient-reported outcomes into large-scale studies to provide robust evidence for changing clinical practice. In particular, interventional oncology trials could be designed to show that certain treatments might be as effective as the current standard of care, but with less morbidity and better outcomes for patients with cancer.

    • James M. Franklin
    • Val Gebski
    • Ricky A. Sharma
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 12, P: 93-104
  • Historically, academic surgeons, so-called surgeon scientists, have been at the forefront of cancer research. However, the role of the surgeon scientist is changing, and concerns have been raised about declines in the number of surgeons performing basic science research alongside clinical activity. Herein, the multifactorial drivers of these changes are discussed and strategies to increase surgical engagement in oncology research are described.

    • Robert. P. Jones
    • Chandrakanth Are
    • Graeme J. Poston
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 16, P: 327-332