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Showing 1–3 of 3 results
Advanced filters: Author: Graham W. Heberlig Clear advanced filters

  • Bacterial Type I polyketide synthases are responsible for producing both lifesaving medicines and virulence factors, yet their stepwise mechanism remains elusive. Here, Burkart et al. characterize acyl carrier protein bound states of mycocerosic acid synthase from Mycobacterium tuberculosis through crosslinking and cryo-EM.

    • Ziran Jiang
    • Graham W. Heberlig
    • Michael D. Burkart
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Structural studies of tyrocidine synthetase using site-selective crosslinking probes to link condensation domains with carrier protein substrates define key interactions and molecular mechanisms of non-ribosomal protein synthesis.

    • Graham W. Heberlig
    • James J. La Clair
    • Michael D. Burkart
    Research
    Nature
    Volume: 638, P: 261-269

  • A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.

    • Nicolas Huguenin-Dezot
    • Diego A. Alonzo
    • Jason W. Chin
    Research
    Nature
    Volume: 565, P: 112-117