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Control of microglial neurotoxicity by the fractalkine receptor

Astrid E Cardona
Erik P Pioro
Richard M Ransohoff
Research18 Jun 2006
Nature Neuroscience

Volume: 9, P: 917-924
A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration

Screening for small-molecule epigenetic modulators identifies HDAC3 inhibitors that promote peripheral myelin repair after nerve injury in rodents.

Xuelian He
Liguo Zhang
Q Richard Lu
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 338-351
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

In this study, the authors report the molecular characterization of orally bioavailable and blood-brain-barrier permeable inhibitors of the nuclear export molecule Xpo1/CRM1 and define the immunomodulatory and neuroprotective effects in preclinical models of inflammatory demyelination and excitatory neurotoxicity.

Jeffery D Haines
Olivier Herbin
Patrizia Casaccia
Research23 Feb 2015
Nature Neuroscience

Volume: 18, P: 511-520
Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Microglia play essential roles in sculpting synaptic connections during brain development but their role in the adult brain is less clear. Here the authors show that activated microglia can prophylactically protect the adult rodent brain from injury by migrating to and displacing inhibitory synapses from cortical neurons.

Zhihong Chen
Walid Jalabi
Bruce D. Trapp
ResearchOpen Access22 Jul 2014
Nature Communications

Volume: 5, P: 1-12
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that elamipretide targets mitochondrial membranes to sustain cristae networks, improving their bioenergetic function.

Mitchell E. Allen
Edward Ross Pennington
Saame Raza Shaikh
ResearchOpen Access17 Jul 2020
Communications Biology

Volume: 3, P: 1-12

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Control of microglial neurotoxicity by the fractalkine receptor

A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

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