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Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living in an area of high malaria transmission in Uganda, to characterize Tfh cells and functional antibodies to multiple parasites stages.

Jo-Anne Chan
Jessica R. Loughland
Michelle J. Boyle
ResearchOpen Access18 Jul 2022
Nature Communications

Volume: 13, P: 1-15
The impact of stopping and starting indoor residual spraying on malaria burden in Uganda

Indoor residual spraying (IRS) of insecticide is one of the primary malaria vector control initiatives, but implementation is limited. Here, the authors show that discontinuation of IRS in Uganda was associated with increased malaria incidence, and introduction of IRS was associated with decreased incidence.

Jane F. Namuganga
Adrienne Epstein
Isabel Rodriguez-Barraquer
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-9
Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy

Control of mosquito populations using pesticides is important for malaria elimination, but effects of pesticides on humans aren’t well understood. Here, Prahl et al. show in a cohort of pregnant Ugandan women and their infants that household spraying with bendiocarb affects the fetal immune system and response to vaccination in infancy.

Mary Prahl
Pamela Odorizzi
Margaret E. Feeney
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-8
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is protective in children against malaria. Here, the authors analyze plasma drug concentration, malaria incidence, and drug resistance markers from a clinical trial in Uganda and determine the optimal DP dosing regimen.

Erika Wallender
Ali Mohamed Ali
Rada M. Savic
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Pareto rules for malaria super-spreaders and super-spreading

Investigating malaria transmission at three sites in Uganda, the authors identify super-spreaders and show that super-spreading is more prominent at low-intensity transmission, and that seasonality and environmental stochasticity have a greater influence on super-spreading.

Laura Cooper
Su Yun Kang
David L. Smith
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-9
Targeted newborn metabolomics: prediction of gestational age from cord blood

Elizabeth A. Jasper
Scott P. Oltman
Kelli K. Ryckman
Research24 Jan 2022
Journal of Perinatology

Volume: 42, P: 181-186
Adjusting vector surveillance for human behaviors reveals Anopheles funestus drove a resurgence in malaria despite IRS with clothianidin in Uganda

Paul Krezanoski
Alex Musiime
Edward K. Thomsen
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-12
Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole

Chloe R. McDonald
Andrea M. Weckman
Kevin C. Kain
ResearchOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1-8
LLIN Evaluation in Uganda Project (LLINEUP)–effects of a vector control trial on Plasmodium infection prevalence and genotypic markers of insecticide resistance in Anopheles vectors from 48 districts of Uganda

Amy Lynd
Samuel Gonahasa
Martin J. Donnelly
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Predicting malaria risk considering vector control interventions under climate change scenarios

Margaux L. Sadoine
Kate Zinszer
Audrey Smargiassi
ResearchOpen Access29 Jan 2024
Scientific Reports

Volume: 14, P: 1-8
The influence of the environment and indoor residual spraying on malaria risk in a cohort of children in Uganda

Margaux L. Sadoine
Audrey Smargiassi
Kate Zinszer
ResearchOpen Access07 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors

Chiara Andolina
Jordache Ramjith
Teun Bousema
ResearchOpen Access01 May 2023
Scientific Reports

Volume: 13, P: 1-16
Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

Shazia Ruybal-Pesántez
Kathryn E. Tiedje
Karen P. Day
ResearchOpen Access18 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

John A. F. Zupancic
Gui-shuang Ying
Gui-shuang Ying
Research28 Feb 2020
Journal of Perinatology

Volume: 40, P: 1100-1108
Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

Prasanna Jagannathan
Fredrick Lutwama
Margaret E. Feeney
ResearchOpen Access13 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Author Correction: Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

Shazia Ruybal-Pesántez
Kathryn E. Tiedje
Karen P. Day
Amendments and CorrectionsOpen Access30 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

Search

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

The impact of stopping and starting indoor residual spraying on malaria burden in Uganda

Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy

Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

Pareto rules for malaria super-spreaders and super-spreading

Targeted newborn metabolomics: prediction of gestational age from cord blood

Adjusting vector surveillance for human behaviors reveals Anopheles funestus drove a resurgence in malaria despite IRS with clothianidin in Uganda

Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole

LLIN Evaluation in Uganda Project (LLINEUP)–effects of a vector control trial on Plasmodium infection prevalence and genotypic markers of insecticide resistance in Anopheles vectors from 48 districts of Uganda

Predicting malaria risk considering vector control interventions under climate change scenarios

The influence of the environment and indoor residual spraying on malaria risk in a cohort of children in Uganda

Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors

Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

Author Correction: Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

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