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Showing 1–2 of 2 results
Advanced filters: Author: Grant P. Grothusen Clear advanced filters

  • The DCAF15 E3 ubiquitin ligase is targeted by aryl-sulfonamide molecular glues leading to neo-substrate proteasomal degradation. Here, the authors reveal DCAF15 as a cell autonomous acute myeloid leukemia dependency sustaining proliferation through control of cohesin complex recycling dynamics.

    • Grant P. Grothusen
    • Renxu Chang
    • Luca Busino
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • p53 inactivation is nearly universal in small-cell lung cancer (SCLC), but its tumor suppressive role in this cancer type is poorly understood. Here the authors show that intertumoral heterogeneity in SCLC influences the biological mechanisms of p53-mediated tumor suppression and identify a role for cyclophilins in p53-dependent necrotic cell death.

    • Jonuelle Acosta
    • Qinglan Li
    • David M. Feldser
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18