The authors demonstrate that the anti-stress peptide neuropeptide Y reduces binge drinking in monkeys and mice by inhibiting neurons in the amygdala that contain the stress peptide corticotropin-releasing factor. Further, the authors find that chronic drinking leads to changes in anti-stress peptide systems that may underlie the pathology stemming from binge drinking.
- Kristen E Pleil
- Jennifer A Rinker
- Thomas L Kash
