Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 151–200 of 588 results
Advanced filters: Author: Gregory B. Lim Clear advanced filters

  • Overexpression of a circular RNA derived from the gene encoding the insulin receptor (Circ-INSR) prevents the development of cardiac dysfunction that occurs in response to anti-cancer therapy with doxorubicin.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 574

  • In mouse transplanted hearts, donor CCR2+ macrophages promote allograft rejection, whereas donor CCR2− macrophages promote allograft survival.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 641

  • Cold shock domain-containing protein E1 (CSDE1) has been identified as a novel post-transcriptional regulator of LDL receptor levels in the liver.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 782

  • Dietary interventions can reduce the risk of cardiovascular events. According to the CORDIOPREV study, a Mediterranean-style diet is superior to a low-fat diet in preventing major cardiovascular events in patients with cardiovascular disease.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 432

  • The addition of acetazolamide to loop diuretic therapy improves the success of decongestion in patients with acute decompensated heart failure and volume overload.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 720

  • Alternative strategies for defibrillation improve outcomes in patients with refractory ventricular fibrillation, according to findings from the DOSE VF trial.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 20, P: 5

  • In the TANDEM and BROADWAY clinical trials, treatment with the CETP inhibitor obicetrapib in addition to background lipid-lowering therapy significantly reduced plasma LDL-cholesterol levels.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 22, P: 463

  • Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.

    • Nigel Turner
    • Xin Ying Lim
    • Anthony S. Don
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Ultra-sensitive cell-free DNA (cfDNA) sequencing uncovers clonal hematopoiesis as a major source of somatic cfDNA variants in healthy individuals and patients with cancer, and underscores the importance of matched white blood cell DNA sequencing in liquid biopsy procedures.

    • Pedram Razavi
    • Bob T. Li
    • Jorge S. Reis-Filho
    Research
    Nature Medicine
    Volume: 25, P: 1928-1937

  • The STROKESTOP trial and The LOOP study used different approaches to screen for atrial fibrillation, with the aim of initiating oral anticoagulation to prevent stroke and death.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 741

  • Endovascular, ultrasound-based renal sympathetic denervation reduces blood pressure in patients with drug-resistant hypertension, according to data from the RADIANCE-HTN TRIO trial.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 543

  • A single-cell RNA-sequencing study in mice shows that, after myocardial infarction, the activated epicardium contains heterogeneous cell populations with distinct gene-expression profiles and paracrine signalling potential, which contribute to the cardioprotective and regenerative responses to ischaemic injury.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 612

  • In the SSaSS trial, substituting regular table salt (100% sodium chloride) with an alternative containing 25% potassium chloride reduced the rate of stroke, major cardiovascular events and all-cause death.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 738-739

  • COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

    • Benedict D. Michael
    • Cordelia Dunai
    • David K. Menon
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • High levels of extracellular glucose induce trained immunity in macrophages, promoting a pro-atherosclerotic phenotype that persists even after normalization of glucose levels.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 687

  • Researchers have developed a cardiac patch that is injectable, maintains its shape and electrically integrates with the myocardium, thereby improving functional recovery after myocardial infarction.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 808

  • In the phase II AXIOMATIC-TKR trial, the oral, selective factor XIa inhibitor milvexian provided dose-dependent protection against venous thromboembolism in patients undergoing knee arthroplasty.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 78

  • In the first 2 weeks after myocardial infarction, endothelial cells can undergo a partial and transient activation of a mesenchymal phenotype before returning to an endothelial state.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 306-307

  • Mineralocorticoid-receptor antagonism with the novel drug finerenone reduces the risk of new-onset atrial fibrillation or flutter in patients with chronic kidney disease and type 2 diabetes mellitus, according to a secondary analysis of the FIDELIO-DKD trial.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 542

  • Antihypertensive therapy, particularly with the use of an angiotensin-converting enzyme inhibitor, improves outcomes in patients with hypertension and SARS-CoV-2 infection, who are susceptible to hyperinflammation and severe outcomes with COVID-19.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 231

  • According to data from the GOAL trial, when latent rheumatic heart disease (RHD) is detected by echocardiographic screening, secondary prophylaxis with antibiotics is effective in preventing progression of the disease.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 79

  • In the QUARTET trial, initial treatment with a single pill containing quarter doses of four antihypertensive drugs achieved and maintained a greater blood-pressure-lowering effect than initial monotherapy with full-dose irbesartan.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 738-739

  • A form of adenine base editing has been used in mouse embryos to correct a genetic variant associated with hypertrophic cardiomyopathy. This approach is potentially safer than other forms of germline gene editing, which carry a risk of off-target editing and the introduction of indels.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 807

  • In ischaemic tissues, macrophages accumulate in the perivascular region and regulate blood flow by releasing nitric oxide derived from inducible nitric oxide synthase, thereby increasing muscle perfusion and improving limb function.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 460

  • Cardiometabolic endoreplication (duplication of the nuclear genome without cell division), resulting in polyploidy and multinucleation, precedes cardiomyocyte hypertrophy in heart disease.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 19, P: 80

  • A deep learning artificial intelligence algorithm applied to recordings from a digital stethoscope can be used to detect cardiac murmurs, aortic stenosis and mitral regurgitation with an accuracy that is similar to that of expert cardiologists.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 460

  • Data from the MASTER DAPT trial indicate that the duration of dual antiplatelet therapy can be abbreviated in patients at high risk of bleeding undergoing implantation of a drug-eluting stent, resulting in a reduction in bleeding risk without an increase in ischaemic events.

    • Gregory B. Lim
    Research Highlights
    Nature Reviews Cardiology
    Volume: 18, P: 740

  • Air surveillance offers a potential means of monitoring airborne pathogens without the need for individual sampling. Here, the authors perform continuous air sampling in 15 community settings in the US for 29 weeks and demonstrate its feasibility for routine detection of SARS-CoV-2 and other respiratory pathogens.

    • Mitchell D. Ramuta
    • Christina M. Newman
    • Shelby L. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14