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Showing 1–6 of 6 results
Advanced filters: Author: Gregory Custer Clear advanced filters
  • Here the authors map the dynamics of human NK cell residency and recirculation, showing that CD56bright NK cells transiently occupy tissues and recirculate via lymphatics, whereas CD56dim NK cells remain vascular except during inflammation.

    • Annika Niehrs
    • Laura Hertwig
    • Niklas K. Björkström
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 2004-2015
  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763
  • Highly accurate antibody tests for SARS-CoV-2 are needed for surveillance in low-prevalence populations. Here, the authors find seroprevalence of less than 1% in two San Francisco Bay Area populations at the beginning of April, and that seroreactivity is generally predictive of in vitro neutralising activity.

    • Dianna L. Ng
    • Gregory M. Goldgof
    • Charles Y. Chiu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7
  • Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engineered to cleave this region degraded RAS in vitro and in cells with a promise of adaptability for other target proteins too.

    • Yingwei Chen
    • Eric A. Toth
    • Philip N. Bryan
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13