GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infection.
- Bryan D. Bryson
- Tracy R. Rosebrock
- Sarah M. Fortune