Nature Search

Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd

A wealth of gene expression data is publicly available, yet is little use without additional human curation. Ma’ayan and colleagues report a crowdsourcing project involving over 70 participants to annotate and analyse thousands of human disease-related gene expression datasets.

Zichen Wang
Caroline D. Monteiro
Avi Ma’ayan
ResearchOpen Access26 Sept 2016
Nature Communications

Volume: 7, P: 1-11
Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

Gregory Lee Szeto
Debra Van Egeren
Darrell J Irvine
ResearchOpen Access22 May 2015
Scientific Reports

Volume: 5, P: 1-13
Persistent serum protein signatures define an inflammatory subcategory of long COVID

Long COVID or post-acute sequelae of SARS-CoV-2 is defined by persisting chronic symptoms following acute SARS-CoV-2 infection but represent an aetiologically diverse group of disorders. Here authors identify molecularly distinct subtypes, including a form with persistent inflammation, via longitudinal analysis of serum proteome.

Aarthi Talla
Suhas V. Vasaikar
Troy R. Torgerson
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-16
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

Existing single-cell RNA-seq methods provide the transcriptome of a cellular phenotype at a single time point. Here, Kimmerlinget al. present a microfluidic platform that enables off-chip single-cell RNA-seq after multigenerational lineage tracking under controlled culture conditions.

Robert J. Kimmerling
Gregory Lee Szeto
Scott R. Manalis
ResearchOpen Access06 Jan 2016
Nature Communications

Volume: 7, P: 1-7
Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα⁺ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Zachary Thomson
Ziyuan He
Claire E. Gustafson
Amendments and CorrectionsOpen Access24 Jan 2024
Nature Immunology

Volume: 25, P: 577
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

An immunotherapy consisting of a tumor-antigen targeting antibody, PD-1 blocking antibody, extended half-life recombinant IL-2 and a lymph-node-targeted T cell vaccine mobilized innate and adaptive immunity and eradicated large established tumors in a variety of mouse models.

Kelly D Moynihan
Cary F Opel
Darrell J Irvine
Research24 Oct 2016
Nature Medicine

Volume: 22, P: 1402-1410
Trimodal single-cell profiling reveals a novel pediatric CD8αα⁺ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Using TEA-seq, Thomson et al. detail transcriptional and epigenetic alterations in the T cell compartment between healthy children and older adults, leading to the discovery of a novel pediatric CD8αα⁺ population poised for rapid effector responses.

Zachary Thomson
Ziyuan He
Claire E. Gustafson
ResearchOpen Access16 Oct 2023
Nature Immunology

Volume: 24, P: 1947-1959
Structure-based programming of lymph-node targeting in molecular vaccines

An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.

Haipeng Liu
Kelly D. Moynihan
Darrell J. Irvine
Research16 Feb 2014
Nature

Volume: 507, P: 519-522
Engineering synthetic vaccines using cues from natural immunity

The clinical application of vaccines has expanded from infectious diseases to cancer, enhancing our vision of how the immune system can be used to prevent and treat disease. This Review highlights recent developments, clinical successes and future challenges in the design of prophylactic, therapeutic and tolerance-inducing synthetic vaccines with inspiration from the natural immune system.

Darrell J. Irvine
Melody A. Swartz
Gregory L. Szeto
Reviews23 Oct 2013
Nature Materials

Volume: 12, P: 978-990
Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device

Annamaria Mocciaro et al. present LACIS, a method for identifying and selecting gene-edited clones using a microfluidic device. The authors apply LACIS to primary T cells after CRISPR-Cas9 editing of CXCR4 and show that selection of edited clones was possible within 10 days from initiation of gene editing.

Annamaria Mocciaro
Theodore L. Roth
Gregory Lavieu
ResearchOpen Access03 May 2018
Communications Biology

Volume: 1, P: 1-8

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