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Showing 1–6 of 6 results
Advanced filters: Author: Gregory Segala Clear advanced filters

  • The engineered hyperfolder YFP (hfYFP) and variants offer unprecedented chemical and thermal stability, making them versatile probes for microscopy as well as for challenging applications like correlative light and electron microscopy and expansion microscopy.

    • Benjamin C. Campbell
    • Maria G. Paez-Segala
    • Ce Feng Liu
    ResearchOpen Access
    Nature Methods
    Volume: 19, P: 1612-1621

  • Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.

    • Gregory Segala
    • Marion David
    • Sandrine Silvente-Poirot
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Endosomal fusion depends on the HOPS and CORVET complexes but whether and how their subunits modulate signal transduction is not fully understood. Here, the authors show that the HOPS/CORVET subunits Vps11 and Vps18 are E3 ubiquitin ligases that are involved in the regulation of ERα signalling.

    • Gregory Segala
    • Marcela A. Bennesch
    • Didier Picard
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • It has been hypothesized that the steroidal alkaloid dendrogenin A (DDA) is a natural metabolite. de Medina et al.show that DDA is produced in mammalian tissues from 5,6α-epoxy-cholesterol and histamine metabolism, and that the compound displays cell differentiation and anti-tumour activities.

    • Philippe de Medina
    • Michael R. Paillasse
    • Marc Poirot
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103