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Showing 1–2 of 2 results
Advanced filters: Author: Gregory Zapas Clear advanced filters

  • The lymphotoxin (LT) system has several defined roles in the regulation of immunity as well as vascular and lymphatic biology, however its role in cancer is less understood. Here the authors show that regulatory T cell-derived LTα1β2 promotes LTβ receptor-nonclassical NFκB signaling in tumor cells and lymphatic endothelial cells, accelerating tumor growth and metastasis.

    • Wenji Piao
    • Long Wu
    • Jonathan S. Bromberg
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Regulatory T (Treg) cells have an important role in the maintenance of immune tolerance and continuously circulate in the body. During this migration, they engage in bidirectional crosstalk with lymphatic and blood endothelial cells, which regulates vascular permeability and determines Treg cell migration patterns and tissue residency. This Review examines the molecular mechanism of these interactions and how they could be targeted in the context of autoimmunity, transplantation and cancer.

    • Wenji Piao
    • Zachariah L. Lee
    • Jonathan S. Bromberg
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 588-607