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Showing 1–10 of 10 results
Advanced filters: Author: Guangxu Lan Clear advanced filters
  • Triacetic acid lactone (TAL) is a platform chemical with a wide range of applications. Here, the authors report the discovery of a polyketoacyl-CoA thiolase from Burkholderia sp. RF2-non_BP3, termed as BktBbr, which has unusually high in vivo and in vitro activity for production of TAL.

    • Zilong Wang
    • Seokjung Cheong
    • Jay D. Keasling
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Artificial enzymes have shown promise for a variety of applications, although their performance is hampered by the limited tunability of current designs. This work introduces a class of artificial enzymes based on metal–organic framework monolayers that feature an amino acid-coordinated metal centre and photoactive cofactors and can be assembled into an efficient artificial photosynthesis system.

    • Guangxu Lan
    • Yingjie Fan
    • Wenbin Lin
    Research
    Nature Catalysis
    Volume: 5, P: 1006-1018
  • Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.

    • Kaiyuan Ni
    • Guangxu Lan
    • Wenbin Lin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13
  • Radiotherapy is known to have local immunomodulatory effects, while an effective systemic immune response is an issue. Here, the authors report on nMOF radiosensitizers for enhanced radiotherapy which in combination with anti-PD-L1 antibodies result in a systemic immune response to distant tumors.

    • Kaiyuan Ni
    • Guangxu Lan
    • Wenbin Lin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • A circular economy for plastics offers a promising solution to the pollution crisis. Here the authors take advantage of the unique chemistry of polydiketoenamine resins, showing how plastics can be biorenewable and recyclable by incorporating biosourced triacetic acid lactone.

    • Jeremy Demarteau
    • Benjamin Cousineau
    • Brett A. Helms
    Research
    Nature Sustainability
    Volume: 6, P: 1426-1435
  • Propionate addition is a common strategy for production of valuable polyketides by supplying the substrate methylmalonyl-CoA in the industrial microbe Corynebacteriumglutamicum; however, propionate inhibits C.glutamicum growth, thus hampering polyketide production. In this study, Zhan et al. identify the reasons for propionate-elicited growth inhibition and metabolically engineer C.glutamicum to circumvent this roadblock and increase polyketide production.

    • Chunjun Zhan
    • Namil Lee
    • Jay D. Keasling
    Research
    Nature Metabolism
    Volume: 5, P: 1127-1140
  • The efficient design of electrochemical CO2 reduction catalysts requires high CO2 concentrations on the catalyst surface. Here, Cui and co-workers make use of flexible, hydrophobic, nanoporous polyethylene membranes with good gas permeability to design a catalytic set-up that mimics the alveolus structure in mammalian lungs, achieving high activity and selectivity to CO.

    • Jun Li
    • Guangxu Chen
    • Yi Cui
    Research
    Nature Catalysis
    Volume: 1, P: 592-600
  • Combining immune checkpoint inhibition with radiotherapy–radiodynamic therapy, enabled by intratumorally injected nanoscale metal–organic frameworks, promotes systemic antitumour immunity and tumour rejection in mouse models of breast and colorectal cancer.

    • Kuangda Lu
    • Chunbai He
    • Wenbin Lin
    Research
    Nature Biomedical Engineering
    Volume: 2, P: 600-610