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Showing 1–3 of 3 results
Advanced filters: Author: Guangxun Yuan Clear advanced filters

  • Inflammasomes are multiprotein complexes, including the protein ASC, that assemble in response to inflammatory stimulation. Here the authors characterise the regulation of ASC during inflammasome formation and show the involvement of SUMOylation and zinc-finger and BTB domain-containing protein 16 (ZBTB16).

    • Danfeng Dong
    • Yuzhang Du
    • Dakang Xu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Although allogeneic chimaeric antigen receptor (CAR)-T cells can overcome manufacturing bottlenecks for cancer immunotherapy, immune rejection reduces the persistence and efficacy of allogeneic cells. Here, the authors demonstrate that CAR-T cells engineered to be resistant to cyclosporin A show improved engraftment and mediate robust tumour-specific responses in allogeneic recipients.

    • Yixi Zhang
    • Hongyu Fang
    • Xun Zeng
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13