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Showing 1–3 of 3 results
Advanced filters: Author: Gui-Lan Li Clear advanced filters

  • Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.

    • Bo Zeng
    • Gui-Lan Chen
    • Shang-Zhong Xu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Members of the transient receptor potential (TRP) ion channels conduct cations into cells upon activation by a variety of signals. Here authors present the cryo-EM structure of TRPC4 in its unliganded (apo) state, which provides molecular insights into TRPC4's ion selectivity and TPR channel evolution.

    • Jingjing Duan
    • Jian Li
    • Jin Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10