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Showing 1–3 of 3 results
Advanced filters: Author: Guillem Portella Clear advanced filters

  • A series of in vitro and in vivo studies has now shown that 5fC is linked to increased nucleosome occupancy and stability. Moreover, there is evidence that Schiff base formation between histones and 5fC impacts RNA polymerase II transcription activity in mouse embryonic stem cells.

    • Eun-Ang Raiber
    • Guillem Portella
    • Shankar Balasubramanian
    Research
    Nature Chemistry
    Volume: 10, P: 1258-1266

  • Whether G-quadruplexes (G4s) regulate stem cell self-renewal and fate determination during embryonic development is not well understood. Here, the authors reveal that the embryonic stem cell state is defined by very high G4 abundance. G4s are progressively lost during differentiation as cells transit to lower lineage potential while artificial G4 stabilisation leads to delayed differentiation.

    • Katherine G. Zyner
    • Angela Simeone
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Parmbsc1, a new force field for DNA simulations, was broadly tested on nearly 100 DNA systems and overcame simulation artifacts that affected previous force fields.

    • Ivan Ivani
    • Pablo D Dans
    • Modesto Orozco
    Research
    Nature Methods
    Volume: 13, P: 55-58