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Showing 1–4 of 4 results
Advanced filters: Author: Gulce Percin Clear advanced filters

  • Haematopoietic stem cells (HSC) are responsible for blood cell generation and reside in the bone marrow. Here, the authors show that macrophages in the bone marrow originate from embryonic or adult haematopoietic lineages and that embryo-derived macrophages are important for the establishment of the HSC pool.

    • Gülce Perçin
    • Konstantin Riege
    • Claudia Waskow
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.

    • Tobias Weinberger
    • Dena Esfandyari
    • Christian Schulz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear. Here the authors show that combined deficiency of FLT3 and CSF1R impedes the differentiation of spleen macrophages of embryonic origin that are required for DC homeostasis.

    • Gulce Itir Percin
    • Jiri Eitler
    • Claudia Waskow
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Multinucleated osteoclasts required for normal bone development and tooth eruption in the mouse originate from embryonic erythro-myeloid progenitors and are maintained after birth by fusion with circulating monocytes.

    • Christian E. Jacome-Galarza
    • Gulce I. Percin
    • Frederic Geissmann
    Research
    Nature
    Volume: 568, P: 541-545