Nature Search

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Integrative analysis of copy number and gene expression in 2,000 primary breast tumours with long-term clinical follow-up revealed putative cis-acting driver genes, novel subgroups and trans-acting aberration hotspots that modulate subgroup-specific gene networks.

Christina Curtis
Sohrab P. Shah
Samuel Aparicio
Research18 Apr 2012
Nature

Volume: 486, P: 346-352
Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

Bernard Pereira
Suet-Feung Chin
Carlos Caldas
Amendments and CorrectionsOpen Access06 Jun 2016
Nature Communications

Volume: 7, P: 1
The shaping and functional consequences of the microRNA landscape in breast cancer

MicroRNA profiling of 1,302 human breast tumour samples provides an overview of the miRNA landscape and its regulation, revealing context-dependent interactions, broad prognostic value of miRNA signatures and an important modulatory role for miRNAs in the biology of breast tumours devoid of copy-number aberrations.

Heidi Dvinge
Anna Git
Carlos Caldas
Research05 May 2013
Nature

Volume: 497, P: 378-382
High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities

Youran Zou
Gulisa Turashvili
Sarah Chiang
Research21 Apr 2020
Modern Pathology

Volume: 33, P: 1861-1870
The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Primary triple-negative breast cancers are shown to vary widely and continuously in the degree of clonal evolution and mutational content at the time of diagnosis, with implications for future studies of the disease.

Sohrab P. Shah
Andrew Roth
Samuel Aparicio
Research04 Apr 2012
Nature

Volume: 486, P: 395-399
Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

Aparicio and colleagues identify gene expression changes in breast cancer datasets putatively associated with age-related endocrine effects, suggesting that patient age may influence the prognostic potential of certain biomarkers.

Tomo Osako
Hakwoo Lee
Samuel Aparicio
Research11 May 2020
Nature Cancer

Volume: 1, P: 518-532
The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

Much effort has recently been devoted to understanding the genomics of breast cancer. In this study, the authors integrate somatic mutation data with previously published copy number aberration and gene expression information for nearly 2,500 breast cancer samples.

Bernard Pereira
Suet-Feung Chin
Carlos Caldas
ResearchOpen Access10 May 2016
Nature Communications

Volume: 7, P: 1-16
The landscape of cancer genes and mutational processes in breast cancer

A study of breast cancers shows that the number of somatic mutations in each varies markedly and is strongly correlated with age at diagnosis and cancer histological grade.

Philip J. Stephens
Patrick S. Tarpey
Michael R. Stratton
Research16 May 2012
Nature

Volume: 486, P: 400-404
Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue

Kristin C Jensen
David F Schaeffer
Matt van de Rijn
Research26 Sept 2008
Modern Pathology

Volume: 21, P: 1413-1420
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

Peter Eirew and his colleagues describe a new assay for detecting, quantifying and characterizing normal human mammary epithelial stem cells. The assay, which combines in vivo transplantation under the kidney capsule of immunodeficient mice and an in vitro colony-forming assay, provides a system for studying the mechanisms regulating normal human mammary stem cell proliferation and differentiation in vivo and in human breast cancer.

Peter Eirew
John Stingl
Connie J Eaves
Research23 Nov 2008
Nature Medicine

Volume: 14, P: 1384-1389
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

Advances in next generation sequencing have made it possible to precisely characterize the coding mutations that occur during the development and progression of individual cancers. Here, this technique is used to sequence the genomes and transcriptomes of an oestrogen-receptor-α-positive metastatic lobular breast cancer; significant evolution is found to occur with disease progression.

Sohrab P. Shah
Ryan D. Morin
Samuel Aparicio
ResearchOpen Access08 Oct 2009
Nature

Volume: 461, P: 809-813
Deep learning detects premalignant lesions in the Fallopian tube

Joep M. A. Bogaerts
John-Melle Bokhorst
Jeroen A. W. M. van der Laak
ResearchOpen Access29 Apr 2024
npj Women's Health

Volume: 2, P: 1-9
P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer

Gulisa Turashvili
Steven E McKinney
Samuel A J R Aparicio
Research17 Sept 2010
Modern Pathology

Volume: 24, P: 64-81

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

The shaping and functional consequences of the microRNA landscape in breast cancer

High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

The landscape of cancer genes and mutational processes in breast cancer

Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

Deep learning detects premalignant lesions in the Fallopian tube

P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer

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