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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

Here the authors show that MRAP2 tunes the melanocortin-4 receptor by boosting its G-protein signaling while limiting β-arrestin2 interaction and destabilizing receptor oligomers, shaping appetite regulation.

Iqra Sohail
Suli-Anne Laurin
Heike Biebermann
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-19
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

The murine G protein-coupled receptor 83 (Gpr83) is expressed widely in the brain, but its physiological role is largely unknown. Here Müller et al.show that Gpr83 regulates systemic energy metabolism in part by modulating ghrelin signalling in the arcuate nucleus of the hypothalamus.

Timo D. Müller
Anne Müller
Matthias H. Tschöp
ResearchOpen Access07 Jun 2013
Nature Communications

Volume: 4, P: 1-8
An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance

Amla Kuechler
Berthold P Hauffa
Jörg Gromoll
Research20 Jan 2010
European Journal of Human Genetics

Volume: 18, P: 656-661
Structure of the actively translating plant 80S ribosome at 2.2 Å resolution

A 2.2 Å cryo-electron microscopy structure of an actively translating 80S ribosome from tobacco reveals bound tRNA and mRNA, the nascent peptide and numerous cofactors, providing a basis for understanding the molecular mechanism of protein synthesis in plants.

Julia Smirnova
Justus Loerke
Reimo Zoschke
ResearchOpen Access08 May 2023
Nature Plants

Volume: 9, P: 987-1000
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

Nicolas A. Heyder
Gunnar Kleinau
Patrick Scheerer
ResearchOpen Access24 Sept 2021
Cell Research

Volume: 31, P: 1176-1189
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Treatment with setmelanotide, a new-generation MC4R agonist, provides durable weight loss in hyperphagic, leptin receptor–deficient patients, suggesting a pharmacological avenue to treat patients with various MC4R pathway defects.

Karine Clément
Heike Biebermann
Peter Kühnen
Research07 May 2018
Nature Medicine

Volume: 24, P: 551-555
Activated mast cells promote differentiation of B cells into effector cells

Anna-Karin E. Palm
Gianni Garcia-Faroldi
Sandra Kleinau
ResearchOpen Access05 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring

Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring-allele is correlated with enhanced cAMP signaling and that both coding and non-coding variants in the TSHR locus contribute to seasonal reproduction.

Junfeng Chen
Huijuan Bi
Leif Andersson
ResearchOpen Access25 Jun 2021
Communications Biology

Volume: 4, P: 1-13

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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance

Structure of the actively translating plant 80S ribosome at 2.2 Å resolution

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Activated mast cells promote differentiation of B cells into effector cells

Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring

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