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Showing 1–4 of 4 results
Advanced filters: Author: Guo-Liang Chew Clear advanced filters

  • Upstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes.

    • Guo-Liang Chew
    • Andrea Pauli
    • Alexander F. Schier
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.

    • Guo-Liang Chew
    • Marie Bleakley
    • Jay Sarthy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Loss of function of the minor spliceosome component ZRSR2 enhances hematopoietic stem cell self-renewal through minor intron retention of its target LZTR1, which is a regulator of RAS-related GTPases. Minor intron retention of LZTR1 was also identified in Noonan syndrome and diverse solid tumor types.

    • Daichi Inoue
    • Jacob T. Polaski
    • Omar Abdel-Wahab
    Research
    Nature Genetics
    Volume: 53, P: 707-718

  • A range of SF3B1 mutations promote tumorigenesis through the repression of BRD9, a core component of the non-canonical BAF complex, and correcting BRD9 mis-splicing in these SF3B1-mutant cells suppresses tumour growth.

    • Daichi Inoue
    • Guo-Liang Chew
    • Robert K. Bradley
    Research
    Nature
    Volume: 574, P: 432-436