Stereodivergent construction of non-adjacent stereocentres remains challenging in asymmetric synthesis, with prior examples limited to one cyclic or allenic stereocentre. Now it has been shown that Ni-catalysed migratory hydroalkylation of trisubstituted alkenes enables enantio- and diastereodivergent access to all four stereoisomers of acyclic molecules bearing remote 1,3- or 1,4-stereocentres.
- Guodong Ju
- Xueyuan Yan
- Chao Wang
