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Showing 1–3 of 3 results
Advanced filters: Author: Gurdeep S. Minhas Clear advanced filters

  • Small molecule antagonists of CCR6 are potential drugs for autoimmune disorders. Here the authors present inactive structures of CCR6 bound by different allosteric antagonists from two series simultaneously, offering multiple approaches to inhibit CCR6.

    • David Jonathan Wasilko
    • Brian S. Gerstenberger
    • Huixian Wu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the respiratory chain in bacteria and mitochondria. Here, the authors present cryo-EM and crystal structures of T. thermophilus complex I in different conformational states and further analyse them by Normal Mode Analysis and molecular dynamics simulations and conclude that quinone redox reactions are important for the coupling mechanism of complex I.

    • Javier Gutiérrez-Fernández
    • Karol Kaszuba
    • Leonid A. Sazanov
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • The atomic-resolution structure of the entire respiratory complex I is reported, with the resolution high enough to map out the locations and orientations of nearly all amino-acid side chains—some of which link to human neurodegenerative diseases—and reveals which amino-acid interactions take place at the hydrophilic domain–membrane domain interface.

    • Rozbeh Baradaran
    • John M. Berrisford
    • Leonid A. Sazanov
    Research
    Nature
    Volume: 494, P: 443-448