Nature Search

Knocking sense into regulatory pathways

Simultaneous targeted perturbations illuminate the structure and function of regulatory networks.

Guri Giaever
Corey Nislow
News & Views01 Feb 2009
Nature Biotechnology

Volume: 27, P: 149-150
Genomic profiling of drug sensitivities via induced haploinsufficiency

Guri Giaever
Daniel D. Shoemaker
Ronald W. Davis
Research01 Mar 1999
Nature Genetics

Volume: 21, P: 278-283
Functional profiling of the Saccharomyces cerevisiae genome

Guri Giaever
Angela M. Chu
Mark Johnston
Research25 Jul 2002
Nature

Volume: 418, P: 387-391
A unique and universal molecular barcode array

Sarah E Pierce
Eula L Fung
Guri Giaever
Research21 Jul 2006
Nature Methods

Volume: 3, P: 601-603
Correction: Corrigendum: An integrated platform of genomic assays reveals small-molecule bioactivities

Shawn Hoon
Andrew M Smith
Corey Nislow
Amendments and Corrections01 Oct 2008
Nature Chemical Biology

Volume: 4, P: 632
Correction: Corrigendum: Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

Genna M Luciani
Lilia Magomedova
Peter J Roy
Amendments and Corrections15 Feb 2012
Nature Chemical Biology

Volume: 8, P: 318
Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery

Andrew R. Burns
Genna M. Luciani
Peter J. Roy
Amendments and CorrectionsOpen Access24 Jul 2020
Nature Communications

Volume: 11, P: 1
Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Agata Nawrotek
Sarah Benabdi
Jacqueline Cherfils
Amendments and Corrections04 Mar 2019
Nature Chemical Biology

Volume: 15, P: 549
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

Robert P St Onge
Ramamurthy Mani
Guri Giaever
Research07 Jan 2007
Nature Genetics

Volume: 39, P: 199-206
Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

By individually replacing 16 yeast genes encoding ABC transporters by GFP, mating and selecting for strains with accumulated mutations the authors create a Green Monster, a strain with deletions in all 16 genes.

Yo Suzuki
Robert P St Onge
Frederick P Roth
Research09 Jan 2011
Nature Methods

Volume: 8, P: 159-164
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

Dafadines, identified in a screen for compounds that induce the dauer phenotype in C. elegans, also promote longevity in adult worms, with both phenotypes occurring through inhibition of DAF-9, a cytochrome P450 involved in the insulin signaling pathway.

Genna M Luciani
Lilia Magomedova
Peter J Roy
Research06 Nov 2011
Nature Chemical Biology

Volume: 7, P: 891-893
Systematic screen for human disease genes in yeast

Lars M. Steinmetz
Curt Scharfe
Ronald W. Davis
Research22 Jul 2002
Nature Genetics

Volume: 31, P: 400-404
PITPs as targets for selectively interfering with phosphoinositide signaling in cells

Phosphatidylinositol transfer proteins (PITPs) are important mediators of phosphoinositide signaling within cells. A small-molecule inhibitor of the PITP Sec14, identified by chemical screening and structure-based design, affects transit through the trans-Golgi network and endosomal system.

Aaron H Nile
Ashutosh Tripathi
Vytas A Bankaitis
Research24 Nov 2013
Nature Chemical Biology

Volume: 10, P: 76-84
Bugs, drugs and chemical genomics

Terry Roemer
Julian Davies
Corey Nislow
Reviews15 Dec 2011
Nature Chemical Biology

Volume: 8, P: 46-56
Microbial and biochemical basis of a Fusarium wilt-suppressive soil

Jae-Yul Cha
Sangjo Han
Youn-Sig Kwak
Research09 Jun 2015
The ISME Journal

Volume: 10, P: 119-129
PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

A small molecule that inhibits the interaction between BRAG2, a guanine-nucleotide exchange factor for the small GTPase Arf, and the membrane affects exchange factor function at the Golgi and suggests a role for BRAG2 in breast cancer.

Agata Nawrotek
Sarah Benabdi
Jacqueline Cherfils
Research11 Feb 2019
Nature Chemical Biology

Volume: 15, P: 358-366
Caenorhabditis elegans is a useful model for anthelmintic discovery

Screening for new anthelmintic compounds that are active against parasitic nematodes is costly and labour intensive. Here, the authors use the non-parasitic nematode Caenorhabditis elegansto identify 30 anthelmintic lead compounds in an effective and cost-efficient manner.

Andrew R. Burns
Genna M. Luciani
Peter J. Roy
ResearchOpen Access25 Jun 2015
Nature Communications

Volume: 6, P: 1-11
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

Knowing a drug's mode of action is invaluable for informing drug discovery efforts. Ho et al. construct an optimized yeast genomic library that enables rapid mutant cloning by complementation to guide mode-of-action studies.

Cheuk Hei Ho
Leslie Magtanong
Charles Boone
Research06 Apr 2009
Nature Biotechnology

Volume: 27, P: 369-377
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

A library of universal Saccharomyces cerevisiae Barcoder strains for efficient tagging is presented. It is used to tag a collection of hypomorphic alleles of essential yeast genes and applied to chemical genetic screens. Also in this issue, Breslow et al. present a similar collection of hypomorphic alleles, coupled with a sensitive growth assay for improved genetic interaction studies.

Zhun Yan
Michael Costanzo
Corey Nislow
Research11 Jul 2008
Nature Methods

Volume: 5, P: 719-725
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

Chemical screening in C. elegans is limited by the relatively poor target accessibility of small molecules. A systematic survey of drug-like small molecule accumulation and metabolism in C. elegans was used to create a computational tool for preselecting compounds likely to effectively perturb worms.

Andrew R Burns
Iain M Wallace
Peter J Roy
Research30 May 2010
Nature Chemical Biology

Volume: 6, P: 549-557
An integrated platform of genomic assays reveals small-molecule bioactivities

Shawn Hoon
Andrew M Smith
Corey Nislow
Research11 Jul 2008
Nature Chemical Biology

Volume: 4, P: 498-506
Correction: Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission

Timothy G. Hammond
Sajanlal R. Panikkanvalappil
Holly H. Birdsall
Amendments and CorrectionsOpen Access29 Oct 2025
Scientific Reports

Volume: 15, P: 1-2
Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission

Timothy G. Hammond
Sajanlal R. Panikkanvalappil
Holly H. Birdsall
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Essential genes have been effectively studied using temperature-sensitive alleles in yeast. Li et al. construct a large collection of temperature-sensitive yeast mutants and show how it enables high-throughput analyses of the function of essential genes.

Zhijian Li
Franco J Vizeacoumar
Charles Boone
Research27 Mar 2011
Nature Biotechnology

Volume: 29, P: 361-367
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell

Magtanong et al. describe the first study to systematically analyze dosage suppression, a type of genetic interaction in which increased dosage of one gene compensates for mutation in another. The authors also develop reagents for future large-scale studies of dosage suppression.

Leslie Magtanong
Cheuk Hei Ho
Charles Boone
Research15 May 2011
Nature Biotechnology

Volume: 29, P: 505-511
Combination chemical genetics

Joseph Lehár
Brent R Stockwell
Corey Nislow
Reviews20 Oct 2008
Nature Chemical Biology

Volume: 4, P: 674-681
A genome-wide portrait of pervasive drug contaminants

Joseph Uche Ogbede
Guri Giaever
Corey Nislow
ResearchOpen Access14 Jun 2021
Scientific Reports

Volume: 11, P: 1-16
Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells

Timothy G. Hammond
Corey Nislow
Holly H. Birdsall
ResearchOpen Access29 Oct 2021
Scientific Reports

Volume: 11, P: 1-19
A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction

Michael A. Kennedy
Tia C. Moffat
Kristin Baetz
ResearchOpen Access13 Jan 2016
Scientific Reports

Volume: 6, P: 1-11
Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures

Sarah E Pierce
Ron W Davis
Guri Giaever
Protocols15 Nov 2007
Nature Protocols

Volume: 2, P: 2958-2974
Author Correction: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells

Timothy G. Hammond
Corey Nislow
Holly H. Birdsall
Amendments and CorrectionsOpen Access24 Nov 2021
Scientific Reports

Volume: 11, P: 1-3

Search

Knocking sense into regulatory pathways

Genomic profiling of drug sensitivities via induced haploinsufficiency

Functional profiling of the Saccharomyces cerevisiae genome

A unique and universal molecular barcode array

Correction: Corrigendum: An integrated platform of genomic assays reveals small-molecule bioactivities

Correction: Corrigendum: Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery

Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

Systematic screen for human disease genes in yeast

PITPs as targets for selectively interfering with phosphoinositide signaling in cells

Bugs, drugs and chemical genomics

Microbial and biochemical basis of a Fusarium wilt-suppressive soil

PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Caenorhabditis elegans is a useful model for anthelmintic discovery

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

An integrated platform of genomic assays reveals small-molecule bioactivities

Correction: Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission

Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell

Combination chemical genetics

A genome-wide portrait of pervasive drug contaminants

Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells

A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures

Author Correction: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells

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