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Advanced filters: Author: Gurkamal Dhaliwal Clear advanced filters

  • During ageing, S-adenosylmethionine (SAM) is depleted from muscle stem cells (MuSCs) because of increased synthesis of the polyamine spermidine, leading to loss of heterochromatin and dysfunction of MuSCs. SAM restoration rescues the mouse MuSC defects.

    • Jengmin Kang
    • Daniel I. Benjamin
    • Thomas A. Rando
    Research
    Nature Metabolism
    Volume: 6, P: 153-168