Poly(ɛ-caprolactone) (PCL) microfiber meshes containing embelin, a poorly water-soluble biactive agent, were prepared by electrospinning. Thermal properties revealed that the crystallinity of embelin was significatively decreased being the drug almost completely dissolved in the PCL fibers. Drug-loading content resulted appropriate for topical applications. Drug-loaded fibrous scaffolds exhibited an increase of 86% in the area-to-volume ratio and provided an effective area per unit mass that was 5.8-fold higher than that presented in drug-loaded films. This polymeric carrier would allow a better in situ bioavailability of embelin.
- Pablo R Cortez Tornello
- Gabriela E Feresin
- Teresita R Cuadrado
