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Showing 1–13 of 13 results
Advanced filters: Author: Guy-Bart Stan Clear advanced filters

  • Synthetic biology is made more reliable by borrowing ideas from systems and control theory.

    • Marios Tomazou
    • Guy-Bart Stan
    News & Views
    Nature Biotechnology
    Volume: 36, P: 313-314

  • Information-bearing templates that catalyse the assembly of complex macromolecules are a central motif of natural biochemistry, but their power remains largely unexplored in synthetic contexts. Enzyme-free templating of DNA dimerization has now been demonstrated, using DNA nanotechnology to ensure that the templates are effective information-propagating catalysts.

    • Javier Cabello-Garcia
    • Rakesh Mukherjee
    • Thomas E. Ouldridge
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 1179-1187

  • In this CRISPR-based feedback control system, sgRNA expression is triggered by the burden of protein overexpression, and the sgRNA directs repression of the exogenous gene promoter to reduce burdensome expression and restore growth of the cell.

    • Francesca Ceroni
    • Alice Boo
    • Tom Ellis
    Research
    Nature Methods
    Volume: 15, P: 387-393

  • Predicting the evolution of engineered cell populations is an increasingly popular topic in biotechnology. Here the authors build a model that explores evolution in engineered cell populations which can generate hypotheses that could lead to important insights into strategies for assessing and mitigating the effects of evolution.

    • Duncan Ingram
    • Guy-Bart Stan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • A challenge in synthetic biology is the empirical characterisation of genetic parts. Here the authors present FPCountR, a validated method and accompanying R package that enables the precise quantification of fluorescent protein reporters per bacterial cell to be enumerated in ‘proteins per cell’ or nanomolar units without requiring protein purification.

    • Eszter Csibra
    • Guy-Bart Stan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The engineering of synthetic microbial communities necessitates the use of synthetic, orthogonal cell-to-cell communication channels. Here the authors present a library of characterised AHL-receiver devices and a software tool for the automatic identification of non-interfering chemical communication channels.

    • Nicolas Kylilis
    • Zoltan A. Tuza
    • Karen M. Polizzi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.

    • Timothy Frei
    • Federica Cella
    • Velia Siciliano
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The translation of heterologous proteins places a burden on host cell resources, affecting growth and productivity. Here the authors develop a cell-free assay to measure resource consumption and predict in vivo burden.

    • Olivier Borkowski
    • Carlos Bricio
    • Tom Ellis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11