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Showing 1–3 of 3 results
Advanced filters: Author: Gwyndalyn Phillips Clear advanced filters

  • The SARS-CoV-2 3CL main protease (3CL Mpro) is a chymotrypsin-like protease that facilitates the production of non-structural proteins, which are essential for viral replication and is therefore of great interest as a drug target. Here, the authors present the 2.30 Å room temperature crystal structure of ligand-free 3CL Mpro and compare it with the earlier determined low-temperature ligand-free and inhibitor-bound crystal structures.

    • Daniel W. Kneller
    • Gwyndalyn Phillips
    • Andrey Kovalevsky
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells.

    • Brian C. Sanders
    • Suman Pokhrel
    • Jerry M. Parks
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17