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Showing 1–8 of 8 results
Advanced filters: Author: Gyanu Lamichhane Clear advanced filters

  • Batchelder et al. report a new penem class antibiotic, T405, which exhibits potent activity against M. abscessus and clinical isolates from cystic fibrosis patients. The development of resistance to T405 is inhibited with the addition of a β-lactamase inhibitor, avibactam. Its clinical potential is further demonstrated by T405 displaying a favourable pharmacokinetic profile in mice with an absence of toxicity.

    • Hunter R. Batchelder
    • Elizabeth Story-Roller
    • Craig A. Townsend
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-5

  • Identification of drug targets in M. tuberculosis is a challenge for bench science. High-throughput mutagenesis with transposons together with microarray-based genome and transcriptome profiling has begun to meet this challenge.

    • Gyanu Lamichhane
    • William Bishai
    News & Views
    Nature Medicine
    Volume: 13, P: 280-282

  • Carbapenem β-lactam antibiotics target non-classical transpeptidases, the L,D-transpeptidases, which act in an alternative Mycobacterium tuberculosis peptidoglycan synthesis pathway, informing the design of evolved carbapenems with improved antibacterial activity.

    • Pankaj Kumar
    • Amit Kaushik
    • Gyanu Lamichhane
    Research
    Nature Chemical Biology
    Volume: 13, P: 54-61

  • Mycobacterium tuberculosis induces a cyclic AMP (cAMP) burst within infected macrophages that influences cell signalling, but the underlying mechanism for this increase in cAMP remains unclear. It is now shown that it is produced by a bacterial adenylate cyclase that facilitates delivery of bacterial-derived cAMP into the macrophage cytoplasm, presumably enhancing virulence through the activation of downstream signalling pathways.

    • Nisheeth Agarwal
    • Gyanu Lamichhane
    • William R. Bishai
    Research
    Nature
    Volume: 460, P: 98-102