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Showing 51–55 of 55 results
Advanced filters: Author: H. Robert Horvitz Clear advanced filters

  • Jan Veldink and colleagues show that loss-of-function variants in NEK1 are associated with susceptibility to amyotrophic lateral sclerosis (ALS). In addition to finding an excess of rare loss-of-function NEK1 variants in ALS cases, they report a significant association between a specific NEK1 missense variant (p.Arg261His) and disease risk.

    • Kevin P Kenna
    • Perry T C van Doormaal
    • John E Landers
    Research
    Nature Genetics
    Volume: 48, P: 1037-1042

  • The genetic architecture of human disease is often hard to replicate in model organisms, and disease modelling in human cells is rapidly improving. Six leading model organism researchers provide their perspective on where this leaves non-human models of disease.

    • Timothy J. Aitman
    • Charles Boone
    • Derek L. Stemple
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 575-582

  • In this Opinion article, the similarities in molecular composition, organization and function of chemosensory receptive endings and neuron–neuron synapses are considered. Based on these parallels, Shai Shaham suggests that chemosensory structures will provide useful models of the neuronal synapse.

    • Shai Shaham
    Reviews
    Nature Reviews Neuroscience
    Volume: 11, P: 212-217

  • Apoptosis is integral to the development of the simple nematode, during which it claims >10% of the somatic cells that are generated. Recent insights into the regulation and execution of apoptosis in this organism will increase our understanding of developmental apoptosis in more complex species.

    • Guillaume Lettre
    • Michael O. Hengartner
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 97-108