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Showing 1–22 of 22 results

Advanced filters: Author: Hadi T. Nia Clear advanced filters

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
A large-scale balloon model of confluent cells validates stress inference from geometry

Joseph K. Hall
Yuqing Deng
Béla Suki
ResearchOpen Access07 Jan 2026
npj Biological Physics and Mechanics

Volume: 3, P: 1-10
Solid stress and elastic energy as measures of tumour mechanopathology

Three methods for releasing solid stress in tumours provide two–dimensional mappings, sensitive estimates and in situ quantification of stress-induced tumour deformations — and thus stored elastic energy — via ultrasonography or optical microscopy.

Hadi T. Nia
Hao Liu
Rakesh K. Jain
Research28 Nov 2016
Nature Biomedical Engineering

Volume: 1, P: 1-11
A CAR enhancer increases the activity and persistence of CAR T cells

Chimeric antigen receptor T cell efficacy is enhanced with an interleukin 2-recruiting molecule.

Taha Rakhshandehroo
Shreya R. Mantri
Mohammad Rashidian
Research30 Jul 2024
Nature Biotechnology

Volume: 43, P: 948-959
ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease

In human spinal ligament tissue exposed to high stress, fibrotic regions displaying elevated Rho-associated kinase signalling and an increased density of myofibroblasts expressing smooth muscle actin α contribute to degenerative spinal disease.

Muhamed Hadzipasic
Margaret S. Sten
Ganesh M. Shankar
Research29 May 2025
Nature Biomedical Engineering

Volume: 9, P: 1677-1690
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

Solid stress generated by brain tumours can cause neurological dysfunction in patients, and this could be countered by administering lithium, according to magnetic resonance imaging of patient brains and mouse models of human brain tumours.

Giorgio Seano
Hadi T. Nia
Rakesh K. Jain
Research07 Jan 2019
Nature Biomedical Engineering

Volume: 3, P: 230-245
Solid stress impairs lymphocyte infiltration into lymph-node metastases

In metastatic lymph nodes, solid stress generated by metastatic growth prevents the infiltration of lymphocytes into the lesions.

Dennis Jones
Zixiong Wang
Timothy P. Padera
Research19 Jul 2021
Nature Biomedical Engineering

Volume: 5, P: 1426-1436
Micromechanics of lung capillaries across mouse lifespan and in positive- vs negative-pressure ventilation

Kathryn Regan
Lauren Castle
Hadi T. Nia
ResearchOpen Access03 Sept 2025
npj Biological Physics and Mechanics

Volume: 2, P: 1-13
Crystal ribcage: a platform for probing real-time lung function at cellular resolution

A fabricated transparent ribcage facilitates real-time analysis of whole-lung function down to cellular resolution.

Rohin Banerji
Gabrielle N. Grifno
Hadi T. Nia
Research14 Sept 2023
Nature Methods

Volume: 20, P: 1790-1801
Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission

Measurements of solid stresses in breast tumours by means of intravital microscopy of tumour-embedded hydrogel beads shows that the transmission of solid stresses depends on length scale and on the tumour microenvironment.

Sue Zhang
Gabrielle Grifno
Hadi T. Nia
Research28 Aug 2023
Nature Biomedical Engineering

Volume: 7, P: 1473-1492
Naturalistic fNIRS assessment reveals decline in executive function and altered prefrontal activation following social media use in college students

Anna Aitken
Ali Rahimpour Jounghani
S. M. Hadi Hosseini
ResearchOpen Access22 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
In vivo compression and imaging in mouse brain to measure the effects of solid stress

This protocol describes how to build and implant an in vivo compression device that simulates the solid mechanical forces exerted on the mouse brain by a growing tumor. Standard transparent cranial windows are adapted to include a turnable screw for controlled compression/decompression.

Hadi T. Nia
Meenal Datta
Rakesh K. Jain
Protocols17 Jul 2020
Nature Protocols

Volume: 15, P: 2321-2340
Probing the physical hallmarks of cancer

This Review discusses the current challenges and the available methods to study the four physical hallmarks of cancer.

Hadi T. Nia
Lance L. Munn
Rakesh K. Jain
Reviews15 Jan 2025
Nature Methods

Volume: 22, P: 1800-1818
Focal white matter disruptions along the cingulum tract explain cognitive decline in amnestic mild cognitive impairment (aMCI)

Elveda Gozdas
Hannah Fingerhut
S. M. Hadi Hosseini
ResearchOpen Access23 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy

Brillouin microscopy can be used to analyze the mechanical properties of cells in a contact-free fashion. Cells in 2D and 3D environments are accessible to this technology, which provides measurements of longitudinal moduli at optical resolution.

Giuliano Scarcelli
William J Polacheck
Seok Hyun Yun
Research05 Oct 2015
Nature Methods

Volume: 12, P: 1132-1134
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian et al. conducted a genome-wide CRISPRi/CRISPRa screen in human neurons and uncovered a neuron-specific link among prosaposin, lipofuscin and ferroptosis. The CRISPRbrain data commons enables comparison of gene function across human cell types.

Ruilin Tian
Anthony Abarientos
Martin Kampmann
Research24 May 2021
Nature Neuroscience

Volume: 24, P: 1020-1034
Quantifying solid stress and elastic energy from excised or in situ tumors

This protocol describes three methods to measure and map solid stress in both excised and in situ tumors of murine and human origin.

Hadi T Nia
Meenal Datta
Rakesh K Jain
Protocols19 Apr 2018
Nature Protocols

Volume: 13, P: 1091-1105
Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure–volume curves

Linzheng Shi
Jacob Herrmann
Béla Suki
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
Long-term cognitive training enhances fluid cognition and brain connectivity in individuals with MCI

Elveda Gozdas
Bárbara Avelar-Pereira
S. M. Hadi Hosseini
ResearchOpen Access23 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-9
Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds

Zeinab Hajjarian
Hadi Tavakoli Nia
Seemantini K. Nadkarni
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks

Bárbara Avelar-Pereira
Michael E. Belloy
S. M. Hadi Hosseini
ResearchOpen Access20 Dec 2022
Molecular Psychiatry

Volume: 28, P: 2423-2432
Identification and prediction of Parkinson’s disease subtypes and progression using machine learning in two cohorts

Anant Dadu
Vipul Satone
Faraz Faghri
ResearchOpen Access16 Dec 2022
npj Parkinson's Disease

Volume: 8, P: 1-12