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Showing 1–5 of 5 results
Advanced filters: Author: Haguy Wolfenson Clear advanced filters

  • The form of vertebrates is shaped by the sensing and relaying of mechanical forces that are applied between cells and their microenvironment. Mechanobiology has emerged as a field of research dedicated to studying these forces and their communication through signalling processes, which are collectively known as mechanotransduction.

    • Thomas Iskratsch
    • Haguy Wolfenson
    • Michael P. Sheetz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 825-833

  • A range of cancer cell types are shown to lack rigidity-sensing due to alteration in specific cytoskeletal sensor proteins and this sensing ability can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.

    • Bo Yang
    • Haguy Wolfenson
    • Michael P. Sheetz
    Research
    Nature Materials
    Volume: 19, P: 239-250

  • Epidermal growth factor receptor and its isoform HER2 are recruited to nascent cellular adhesion sites and play an important role in the rigidity sensing of cells on stiff substrates, this activity being dependent on Src-mediated phosphorylation.

    • Mayur Saxena
    • Shuaimin Liu
    • Michael P. Sheetz
    Research
    Nature Materials
    Volume: 16, P: 775-781