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Continuous base identification for single-molecule nanopore DNA sequencing

A protein nanopore with a permanent adaptor molecule can continuously identify unlabelled DNA bases with ∼99.8% accuracy. This level of performance could provide the foundation for the development of nanopore-based DNA sequencing technologies that are faster and less expensive than existing approaches.

James Clarke
Hai-Chen Wu
Hagan Bayley
Research22 Feb 2009
Nature Nanotechnology

Volume: 4, P: 265-270
Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection

A nanopore-based enzyme-linked immunosorbent assay is developed for the single-molecule sensing of distinct current signatures from peptide probes generated on translocation through α-hemolysin after enzymatic cleavage, enabling the multiplexed detection of biomarkers in blood samples.

Yakun Yi
Peng Song
Hai-Chen Wu
Research14 May 2025
Nature Nanotechnology

Volume: 20, P: 1079-1086
Peptide sequencing based on host–guest interaction-assisted nanopore sensing

A phenylalanine-containing peptide probe can be used for discriminating all 20 amino acids via current blockage during translocation through an α-hemolysin (αHL) nanopore. The paper provides proof-of-concept peptide sequencing demonstrations.

Yun Zhang
Yakun Yi
Hai-Chen Wu
Research13 Nov 2023
Nature Methods

Volume: 21, P: 102-109
High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes

Ultrashort single-walled carbon nanotubes inserted in lipid bilayers can be used as nanopore sensors. Here, the authors demonstrate the high-resolution discrimination of homologous and isomeric proteinogenic amino acids with such carbon-based nanopores.

Weichao Peng
Shuaihu Yan
Yuliang Zhao
ResearchOpen Access09 May 2023
Nature Communications

Volume: 14, P: 1-8
Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor

Nanopore sensors are a promising tool for the controlled detection of a range of possible substrates. Here the authors describe a nanopore sensor based on short single-walled carbon nanotubes inserted into a lipid bilayer, with modified sensing properties compared to longer nanotubes.

Lei Liu
Chun Yang
Hai-Chen Wu
ResearchOpen Access19 Dec 2013
Nature Communications

Volume: 4, P: 1-8
Use of selective serotonin-reuptake inhibitors in the first trimester and risk of cardiovascular-related malformations: a meta-analysis of cohort studies

Tie-Ning Zhang
Shan-Yan Gao
Qi-Jun Wu
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
Fabrication of nanopores with ultrashort single-walled carbon nanotubes inserted in a lipid bilayer

When an electric field is applied across a membrane containing nanopores, it induces an ion current that alters upon ligand binding. Single-walled carbon nanotubes form nanopores that can be used as sensors; specificity is a function of pore size.

Lei Liu
Jiani Xie
Hai-Chen Wu
Protocols01 Oct 2015
Nature Protocols

Volume: 10, P: 1670-1678

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Continuous base identification for single-molecule nanopore DNA sequencing

Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection

Peptide sequencing based on host–guest interaction-assisted nanopore sensing

High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes

Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor

Use of selective serotonin-reuptake inhibitors in the first trimester and risk of cardiovascular-related malformations: a meta-analysis of cohort studies

Fabrication of nanopores with ultrashort single-walled carbon nanotubes inserted in a lipid bilayer

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