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Nature Communications (4)

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Showing 1–4 of 4 results

Advanced filters: Author: Haifan Gong Clear advanced filters

Peripheral blood DNA methylation predicts the early onset of primary tumor in TP53 mutation carriers

Li-Fraumeni syndrome leads to an increased predisposition to tumour development. Here, the authors develop a support vector machine model to predict early cancer risk in individuals using peripheral blood DNA methylation profiles.

Vallijah Subasri
Benjamin Brew
Anna Goldenberg
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-12
PUMILIO proteins promote colorectal cancer growth via suppressing p21

RNA binding proteins can contribute to colorectal cancer (CRC) initiation and development. Here the authors show that PUMILIO proteins, PUM1 and PUM2 contribute to CRC growth by inhibiting p21 expression.

Yuanyuan Gong
Zukai Liu
Sanhong Liu
ResearchOpen Access25 Mar 2022
Nature Communications

Volume: 13, P: 1-17
Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

Wang et al. clarify the regional heterogeneity of intestinal AMPs and identify that chromatin accessibility determines the potential of BATFs to regulate AMPs at the pre-transcriptional level, thus shaping the regional heterogeneity of AMPs.

Yue Wang
Yanbo Yu
Yanqing Li
ResearchOpen Access22 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns

Here, Wong et al investigate the cell-free DNA landscape of individuals with Li-Fraumeni syndrome (LFS), a cancer predisposition, and find altered composition compared to non-LFS individuals which can be used to detect and track cancer development.

Derek Wong
Maha Tageldein
Trevor J. Pugh
ResearchOpen Access27 Aug 2024
Nature Communications

Volume: 15, P: 1-16