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Showing 1–3 of 3 results
Advanced filters: Author: Haijuan Qin Clear advanced filters

  • Despite the structural significance of boroxines in different classes of materials, their applicability in aqueous media is limited by their hydrolytic instability. Here, the authors discovered a water-stable boroxine structure with excellent pH stability and water-compatible dynamic covalent bonds.

    • Xiaopei Li
    • Yongjie Zhang
    • Guangyan Qing
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Sialylated glycans (SGs), abundant in cell membranes, play decisive roles in regulating ion channels (e.g., NaV1.4, KV1.1, CaV1.2) in life system, only when the ion channels work stably and accurately can life activities proceed normally. Here we construct a biomimetic SG-modulated nanochannel based on a smart polymer design. Carbohydrate‒carbohydrate interaction triggers globule-to-coil transition of the polymer chains, which regulated the dynamic ion gating behavior of this nanochannel, resulting in a significant reduction in transmembrane ionic current. This device exhibits excellent specificity and sensitivity in response to α-2,6-linked sialyllactose, further realizing real-time monitoring of the sialylation reaction catalyzed by α2,6-sialyltransferase.

    • Jie Xiao
    • Wenqi Lu
    • Guangyan Qing
    ResearchOpen Access
    NPG Asia Materials
    Volume: 14, P: 1-14

  • Inspired from Ca2+-induced Ca2+ release process responsible for Ca2+ channel and muscle contraction, a smart Ca2+ self-regulated nanochannel system is constructed by the convergence of a Ca2+-responsive polymer with porous anodic alumina membrane. Dynamic gating behavior of the nanochannel could be precisely modulated by Ca2+ concentration utilizing remarkable conformational transition of the copolymer chains from globule to coil.

    • Yunlong Li
    • Yuting Xiong
    • Guangyan Qing
    ResearchOpen Access
    NPG Asia Materials
    Volume: 11, P: 1-13