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Showing 1–4 of 4 results
Advanced filters: Author: Haixia Zhai Clear advanced filters

  • Precise analysis of DNA–protein interactions can help to better understand various biological processes. Now, the ‘light-induced lysine (K) enabled crosslinking’ strategy (shortened to ‘LIKE-XL’) has been developed for spatiotemporal and global profiling of DNA–protein interactions, affording the discovery of low-affinity interactions between transcription factors and DNA using sequence-specific DNA baits.

    • An-Di Guo
    • Ke-Nian Yan
    • Xiao-Hua Chen
    Research
    Nature Chemistry
    Volume: 15, P: 803-814

  • Skeletal muscle stem cells (satellite cells) express different levels of a critical transcriptional regulator Pax7. Here, the authors show that miR-431 regulates Pax7 levels in satellite cells of the developing and regenerating muscle, and that increased miR-431expression in these cells alleviates symptoms of muscular dystrophy in mice.

    • Rimao Wu
    • Hu Li
    • Dahai Zhu
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • DNA methylation contributes to transcriptional silencing. Here, Groth et al.show that mutant plants defective in MTHFD1, an enzyme involved in folate metabolism, have a DNA hypomethylation phenotype highlighting the link between one-carbon metabolism and DNA methylation, which is mediated by SAM as a common methyl donor.

    • Martin Groth
    • Guillaume Moissiard
    • Steven E. Jacobsen
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13