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Showing 1–19 of 19 results
Advanced filters: Author: Hal Drakesmith Clear advanced filters

  • Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that aspartate is increased yet downstream nucleotide synthesis is suppressed and addition of exogenous aspartate partially rescues T cell function.

    • Megan R. Teh
    • Nancy Gudgeon
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may explain the ancient synteny of α -globin with Nprl3.

    • Alexandra E. Preston
    • Joe N. Frost
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • In recent years, the interactions between viruses and cellular metabolism have become a topic of great interest. Viral infections that disrupt liver function can be accompanied by changes in iron homeostasis, and iron loading of the liver can exacerbate chronic viral disease. Here, Hal Drakesmith and Andrew Prentice consider some examples of how viruses such as HIV-1, hepatitis C virus and arenaviruses manipulate cellular iron metabolism.

    • Hal Drakesmith
    • Andrew Prentice
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 541-552

  • Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

    • Sant-Rayn Pasricha
    • Pei Jin Lim
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Metabolic alterations control the fate and function of immune cells in response to infections, but the function of NK cell metabolism in the context of acute viral infections is unclear. Here the authors show that acute NK cell responses to Friend retrovirus involve increased glycolysis and mitochondrial metabolism and require amino acid transport as well as iron sufficiency.

    • Elisabeth Littwitz-Salomon
    • Diana Moreira
    • David K. Finlay
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Hepatitis C virus (HCV) infection blunts induction of hepcidin expression by bone morphogenetic protein 6 (BMP6), probably via TNF-mediated downregulation of the BMP co-receptor HJV, while BMP6 regulates a gene repertoire reminiscent of type I IFN signalling. BMP6 and related activin proteins potently block replication of HCV, hepatitis B virus and Zika virus independently of IFN.

    • Lucy A. Eddowes
    • Kinda Al-Hourani
    • Hal Drakesmith
    Research
    Nature Microbiology
    Volume: 4, P: 339-351

  • Iron homoeostasis is tightly orchestrated to avoid toxic iron overload. Here Lim and colleagues show that iron excess activates Nrf2 via mitochondrial reactive oxygen species, enhancing the expression of Bmp6 in liver sinusoidal endothelial cells, which in turn promotes hepcidin expression by hepatocytes, decreasing systemic iron levels.

    • Pei Jin Lim
    • Tiago L. Duarte
    • Hal Drakesmith
    Research
    Nature Metabolism
    Volume: 1, P: 519-531

  • The AIDS pandemic is caused by human immunodeficiency virus, which was discovered at the Institut Pasteur in 1983. In May 2008, scientists met in Paris to discuss the progress and setbacks of 25 years of research in this field and to debate future directions.

    • Andrew E Armitage
    • Andrew J McMichael
    • Hal Drakesmith
    News & Views
    Nature Immunology
    Volume: 9, P: 823-826

  • Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and humoral responses affecting protection against infections, tumours and autoimmunity.

    • Joe N. Frost
    • Hal Drakesmith
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 885-899

  • Superinfection with Plasmodium species increases the risk of fatal disease in individuals with low immunity, yet it is not frequent in young children. Portugal et al. provide a possible explanation for this dichotomy, showing that blood-stage parasitemia in mice inhibits liver-stage development of a second Plasmodium species infection due to iron sequestration.

    • Silvia Portugal
    • Céline Carret
    • Maria M Mota
    Research
    Nature Medicine
    Volume: 17, P: 732-737

  • Aulicino, Antanaviciute et al investigate the transcriptional response to invasive Salmonella strains in dendritic cells (DCs). They show that S. Typhi mount a response against nitrosative stress pathways and propose a role of iron uptake and transport in preventing infection, which the pathogen can bypass. In parallel, they find that invasive Salmonella employs several mechanisms targeting more classic aspects of immunity to impair DC function.

    • Anna Aulicino
    • Agne Antanaviciute
    • Alison Simmons
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-17