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Advanced filters: Author: Hala Abou Assi Clear advanced filters

Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape

The functions of small nucleolar RNAs (snoRNAs) in cancer remain to be studied. Here the authors show that the snoRNA Snord67 promotes lymph node metastasis of breast cancer cells through guiding modifications of the spliceosome and regulating the splicing landscape.

Yvonne L. Chao
Katherine I. Zhou
Chad V. Pecot
ResearchOpen Access02 May 2025
Nature Communications

Volume: 16, P: 1-23
Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo

The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.

Brittany A. Elliott
Hsiang-Ting Ho
Christopher L. Holley
ResearchOpen Access30 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction

Determining dynamic ensembles of biomolecules is still challenging. Here the authors present an approach for rapid RNA ensemble determination that combines RNA structure prediction tools and NMR residual dipolar coupling data and use it to determine atomistic ensemble models for a variety of RNAs.

Honglue Shi
Atul Rangadurai
Hashim M. Al-Hashimi
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-14

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