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Showing 1–3 of 3 results
Advanced filters: Author: Haley E. Randolph Clear advanced filters

  • Somatically determined preferential allelic expression of select genes that when mutated cause inborn errors of immunity corresponds with disease phenotypes, suggesting that the penetrance and expressivity of monogenic disorders is also dependent on the ‘transcriptotype’.

    • O’Jay Stewart
    • Conor Gruber
    • Dusan Bogunovic
    Research
    Nature
    Volume: 637, P: 1186-1197

  • The role of IFN signaling in SARS-CoV-2 infection and outcome is still debated. Here, the authors longitudinally profiled plasma samples from hospitalized patients and show that a persistent inflammatory response is linked to delayed generation of adaptive immunity and increased risk of death when coupled with severe infection.

    • Elsa Brunet-Ratnasingham
    • Sacha Morin
    • Daniel E. Kaufmann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19