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Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron

Current vaccines induce broadly cross-reactive cellular immunity against SARS-CoV-2 variants, including Omicron, and provide protection against severe disease despite a substantially reduced neutralizing antibody response.

Jinyan Liu
Abishek Chandrashekar
Dan H. Barouch
ResearchOpen Access31 Jan 2022
Nature

Volume: 603, P: 493-496
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

In a phase 1 trial, a lymph node-targeting mutant KRAS peptide vaccine combined with CpG adjuvant is safe, reduces expression of tumor biomarkers and elicits mutant KRAS-specific T cells in patients with pancreatic cancer and colorectal cancer.

Shubham Pant
Zev A. Wainberg
Eileen M. O’Reilly
ResearchOpen Access09 Jan 2024
Nature Medicine

Volume: 30, P: 531-542

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Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

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