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Showing 1–5 of 5 results
Advanced filters: Author: Hamed Alborzinia Clear advanced filters

  • Alborzinia et al. report that MYCN-amplified neuroblastoma undergoes ferroptosis in the absence of intracellular cysteine, suggesting a combination of cysteine depletion and concomitant GPX4 inactivation as a potential therapeutic approach.

    • Hamed Alborzinia
    • Andrés F. Flórez
    • Frank Westermann
    ResearchOpen Access
    Nature Cancer
    Volume: 3, P: 471-485

  • Hamed Alborzinia et al. show that Golgi-dispersing compounds trigger iron-dependent oxidative degradation of lipids, inducing a non-apoptotic cell death called ferroptosis. This study provides insight into the role of Golgi apparatus for preventing ferroptotic cell death through its cellular redox control.

    • Hamed Alborzinia
    • Tatiana I. Ignashkova
    • Jan H. Reiling
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-15

  • Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

    • Florencio Porto Freitas
    • Hamed Alborzinia
    • José Pedro Friedmann Angeli
    Research
    Nature
    Volume: 626, P: 401-410