Nature Search

Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

André Franz
Paul A. Pirson
Thorsten Hoppe
Amendments and CorrectionsOpen Access17 May 2016
Nature Communications

Volume: 7, P: 1-2
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.

Melanie Fritsch
Saskia D. Günther
Hamid Kashkar
Research20 Nov 2019
Nature

Volume: 575, P: 683-687
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

The lipopolysaccharide of the intracellular pathogen Shigella, in particular its O antigen, interacts with caspases and blocks their activation to prevent apoptosis.

Saskia D. Günther
Melanie Fritsch
Hamid Kashkar
Research23 Dec 2019
Nature Microbiology

Volume: 5, P: 354-367
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.

Jessica Gräb
Isabelle Suárez
Jan Rybniker
ResearchOpen Access08 Feb 2019
Nature Communications

Volume: 10, P: 1-14
CD4⁺ T cell-induced inflammatory cell death controls immune-evasive tumours

This article describes a mechanism through which CD4⁺ T cells can eradicate MHC-deficient tumours that escape direct CD8⁺ T cell targeting and thereby complement the activity of CD8⁺ T cells and natural killer cells to advance cancer immunotherapies.

Bastian Kruse
Anthony C. Buzzai
Thomas Tüting
ResearchOpen Access14 Jun 2023
Nature

Volume: 618, P: 1033-1040
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

Marie-Christine Albert
Kerstin Brinkmann
Hamid Kashkar
ResearchOpen Access10 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-15
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks.

André Franz
Paul A. Pirson
Thorsten Hoppe
ResearchOpen Access04 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes

Granules containing perforin and granzymes are secreted from cytotoxic T lymphocytes. Krönke and co-workers find that acid sphingomyelase is needed for granule shrinkage just before exocytosis in this process.

Jasmin Herz
Julian Pardo
Olaf Utermöhlen
Research14 Jun 2009
Nature Immunology

Volume: 10, P: 761-768
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

Upregulation of microRNA-143 occurs in livers of obese mice. Transgenic overexpression of miR-143 in mice leads to insulin resistance through downregulation of the oxysterol-binding protein-related protein ORP8, impairing Akt activation in response to insulin.

Sabine D. Jordan
Markus Krüger
Jens C. Brüning
Research27 Mar 2011
Nature Cell Biology

Volume: 13, P: 434-446
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis

Saita et al. show that PARL cleaves Smac (also known as DIABLO) to generate an IAP-binding motif required for its apoptotic activity, identifying PARL-mediated Smac processing as a pro-apoptotic mitochondrial pathway.

Shotaro Saita
Hendrik Nolte
Thomas Langer
Research13 Mar 2017
Nature Cell Biology

Volume: 19, P: 318-328
Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer

Lars Mortimer Schiffmann
Melanie Fritsch
Oliver Coutelle
ResearchOpen Access31 Oct 2018
British Journal of Cancer

Volume: 120, P: 69-78
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

Riboflavin kinase is shown to couple TNF receptor 1 to reactive oxygen production by the FAD-dependent NADPH oxidase.

Benjamin Yazdanpanah
Katja Wiegmann
Martin Krönke
Research29 Jul 2009
Nature

Volume: 460, P: 1159-1163
Primary cilia suppress Ripk3-mediated necroptosis

Emilia Kieckhöfer
Gisela G. Slaats
Bernhard Schermer
ResearchOpen Access02 Dec 2022
Cell Death Discovery

Volume: 8, P: 1-12
Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

Sebastian J. Theobald
Jessica Gräb
Jan Rybniker
ResearchOpen Access30 Oct 2021
Cell Death Discovery

Volume: 7, P: 1-14
ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers

Matthias Kirschberg
Sandra Heuser
Baki Akgül
ResearchOpen Access15 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants

Takaki Maekawa
Hamid Kashkar
Núria S. Coll
ReviewsOpen Access04 Oct 2022
Cell Death & Differentiation

Volume: 30, P: 258-268
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154

Search

Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

CD4⁺ T cell-induced inflammatory cell death controls immune-evasive tumours

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis

Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

Primary cilia suppress Ripk3-mediated necroptosis

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers

Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Search

Quick links

Search

Filter By:

Search

Quick links