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Showing 1–2 of 2 results
Advanced filters: Author: Hamida Laroussi Clear advanced filters

  • Unwanted RNA transcripts are targeted for degradation by nuclear complexes such as MTREC/PAXT. Here, the authors structurally and functionally characterized three interfaces of the scaffold protein Red1, providing mechanistic insights into conserved features of MTREC/PAXT architecture.

    • Anne-Emmanuelle Foucher
    • Leila Touat-Todeschini
    • Jan Kadlec
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • TOPOVIBL and REC114 are required for meiotic DNA double-strand breaks (DSBs). This study shows that TOPOVIBL forms a complex with REC114 and mice carrying mutations that disrupt the interaction show DSB defects with distinct outcomes in males and females.

    • Alexandre Nore
    • Ariadna B. Juarez-Martinez
    • Bernard de Massy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19