DNA can be amplified and sequenced from a single cell, but unevenness of the sequence coverage complicates efforts to assemble a high-quality genome. Chitsaz et al. devise an algorithm to address this problem and apply it to assemble a genome draft of an uncultured single-cell marine organism from one lane of Illumina sequence data.
- Hamidreza Chitsaz
- Joyclyn L Yee-Greenbaum
- Roger S Lasken
