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Showing 1–3 of 3 results
Advanced filters: Author: Hampus Hedlund Clear advanced filters

  • Lipid nanoparticles (LNPs) fate after up take by cells is important for therapies. Here, the authors report on key barriers limiting RNA delivery by LNPs, including restricted endosomal escape, ESCRT-mediated membrane repair, and separation of lipid and RNA components during endosomal sorting.

    • Johanna M. Johansson
    • Hampus Du Rietz
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small molecule membrane-destabilising drugs.

    • Hampus Du Rietz
    • Hampus Hedlund
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Endosomal escape and subsequent cytosolic delivery of siRNA therapeutics is inefficient, and quantification is difficult. Here the authors report a confocal microscopy-based method to quantify cytosolic delivery of fluorescently labelled siRNA during lipid-mediated delivery.

    • Hampus Hedlund
    • Hampus Du Rietz
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14