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Showing 1–10 of 10 results
Advanced filters: Author: Han Zuilhof Clear advanced filters

  • Precise control over both sequence and chirality remains a challenge in polymer chemistry. Here sulfur–fluoride exchange and sulfur–phenolate exchange reactions are used to create chiral oligosulfonimidates with tunable sulfur-centred chirality. This strategy enables precise three-dimensional structural control over oligomers and polymers, marking a step towards fully nature-mimicking macromolecules.

    • Yu Han
    • Sidharam P. Pujari
    • Han Zuilhof
    ResearchOpen Access
    Nature Synthesis
    Volume: 4, P: 1106-1117

  • Chirality plays a critical role in the structure and function of natural and synthetic polymers, impacting their properties. Here, the authors achieve single-chain chemical analysis to unravel the emergence of different forms of chirality from small molecules to their resulting polymers and supramolecular assemblies.

    • Xuecong Li
    • Sidharam P. Pujari
    • Francesco Simone Ruggeri
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Sulfur(vi) fluoride exchange (SuFEx)—a type of click chemistry that generates SVI-centred covalent linkages—has previously been used for polymer synthesis. Now, modular SuFEx polymerization using SOF4 has been used to generate helical polymers. Unlike previous examples of SuFEx polymerization, the backbone retains SVI–F motifs and therefore is able to undergo further SuFEx click reactions, enabling facile and efficient post-polymerization modification.

    • Suhua Li
    • Gencheng Li
    • K. Barry Sharpless
    Research
    Nature Chemistry
    Volume: 13, P: 858-867

  • Click chemistry is widely used in organic and materials chemistry. Now, a divergent sulfur(VI) fluoride exchange process provides access to a range of synthetically valuable vinylic and acetylenic sulfoximine products.

    • Fedor Miloserdov
    • Han Zuilhof
    News & Views
    Nature Synthesis
    Volume: 1, P: 415-416

  • Sulfur fluoride exchange (SuFEx) is a click reaction used to rapidly synthesize and discover functional molecules. In this Primer, Homer et al. discuss the essential elements of SuFEx operation, catalysis and SuFExable connective hubs and explore applications of SuFEx in drug development, polymer science and biochemistry.

    • Joshua A. Homer
    • Long Xu
    • John E. Moses
    Reviews
    Nature Reviews Methods Primers
    Volume: 3, P: 1-17

  • Beekman et al. investigate whether low molecular weight organosilicon compounds leaching out of commonly used biological laboratory materials and household items can interact with molecules found in cellular membranes. The results suggest this is a passive process by physicochemical forces rather than active uptake.

    • Pepijn Beekman
    • Agustin Enciso-Martinez
    • Cees Otto
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-8